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Additional info for A Symposium on Mechanisms of Toxicity
This showed that only one of the diastereoisomers ofL-methionine 10 0 Time after adding inhibitor (min) FIG. 14. Inhibition of glutamine synthetase by the diastereoisomers of Lmethionine sulphoximine. M), imidazole-HCI buffer (pH 7·2; 0·05 M), 2-mercaptoethanol (0·001 M), ATP (0·005 M), MgCb (0·01 M) and the following; • - • · L-methionine-R-sulphoximine (1·0 mM); /::;-/::;, L-methionine-R-sulphoximine (5·0 mM); e-e, L-methionine-SR-sulphoximine (1·0 mM); 0-0, L-methionine-S-sulphoximine (0·5 mM); final volume, 0·05 mi.
The hexobarbitone, if given alone, produces a hypothermia of 1 to 1·5° in about half an hour, which is completely over within 2 h. Fig. 1 also shows that atropine administered a few minutes before the anti-ChE markedly reduces the hypothermia, although it is unable to prevent it completely. Fig. 1 shows the maximum antidotal effect of atropine obtained following an extremely high dose (50 mgfkg, intraperitoneally). Increasing the dose beyond this level produces no better effect, and may kill the rats.
B. Rowe, J. D. Gass, & S. L. N. Rao There is now substantial evidence that an enzyme-bound y-glutamyl phosphate intermediate is formed during glutamine synthesis. , 1956). , 1966). The well known tendency of certain y-glutamyl derivatives to cyclize to yield pyrrolidone carboxylic acid suggested experiments in which glutamine synthetase was incubated with ATP and glutamate in the absence of ammonia. , 1962). It was subsequently found that pyrrolidone carboxylic acid is indeed formed in these conditions and that the rates of cyclization are about the same with L- and D-glutamic acid.