By I Barry Holland, Susan P. C. Cole, Karl Kuchler, Christopher F. Higgins
ABC Proteins is an in-depth, updated research of all that's identified in regards to the topic thus far. It discusses and compares evolution, biology and mechanism of motion of all identified ABC proteins, together with the 1st structural experiences in addition to medical implications. it will likely be invaluable to someone attempting to remain abreast of the most recent findings. This publication is certain to turn into a vintage and may on a regular basis be up to date. Key good points* Phylogeny and Evoloution of ABC Transporters* primary facets of the Mechanism of motion of ABC Transporters* Prokaryote ABC Transporters* Non-Mammalian Transporters* Multidrug Transporters* ABC Transporters, Physiological Roles and Human disorder* complete colour all through
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Extra info for ABC Proteins: From Bacteria to Man
D. (2000) Sub-cellular localisation of the white/scarlet ABC transporter to pigment granule membranes within the compound eye of Drosophila melanogaster. Genetica 108, 239–252. , Chakraburtty, K. G. (1997) Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2. Mol. Cell. Biol. 17, 4474–4489. C. E. (1997) Temperature-sensitive lesions in the Francisella novicida valA gene cloned into an Escherichia coli msbA lpxK mutant affecting 31 32 ABC PROTEINS: FROM BACTERIA TO MAN deoxycholate resistance and lipopolysaccharide assembly at the restrictive temperature.
1999). , 2000). ABCA1 regulates HDL levels and is considered to control the first step of cellular reverse cholesterol transport from the periphery to the liver by transferring cellular cholesterol and phospholipids to apolipoproteins. , 2001). , 1997; Azarian and Travis, 1997) (see also Chapter 28). The ABCR protein is located in retina rod outer segment disks. , 1999). At least 11 other human genes encoding ABCA systems have been identified. These include ABCA2, which is highly expressed in brain, ABCA3, which is homologous to the C.
H. (2000) Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 290, 1771–1775. , Distler, J. and Piepersberg, W. 0 (ETH 22794): new operons and evidence for pathway-specific regulation by StrR. Mol. Gen. Genet. 250, 775–784. , Lebleu, B. and Salehzada, T. (1995) Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. J. Biol. Chem. 270, 13308–13317. , Le Roy, F. and Salehzada, T. (2000) The 2Ј-5Ј oligoadenylate/ RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation.