Download Age-related Macular Degeneration by L. Ho, R. van Leeuwen, P. T. V. M. de Jong, J. R. PDF

By L. Ho, R. van Leeuwen, P. T. V. M. de Jong, J. R. Vingerling, C. C. W. Klaver (auth.), Frank G. Holz, Daniel Pauleikhoff, Richard F. Spaide, Alan C. Bird (eds.)

Age-related macular degeneration is the commonest reason for the lack of valuable imaginative and prescient past the age of fifty in business countries. Triplication of the variety of affected sufferers is anticipated over the following 25 years. specially during the last years the normal of information relating to etiology, possibility elements, diagnostics and remedy of this retina sickness has considerably grown – this can be coated during this updated multi-authored paintings. except epidemiologically and genetically pointed out chance elements either a number of the pathophysiological features together with the function of the supplement approach and medical manifestations together with OCT and angiographic features are essentially represented. additionally, the various healing techniques are provided and mentioned, together with confirmed methods resembling intravitreal anti-VEGF remedy and seeing-aid structures, as well as the newest and upcoming tools within the region of pharmacology. the quantity is well-illustrated and tables and summaries whole the presentation.

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Ophthalmologe 91(6):735–740 Mitchell P, Foran S (2005) Age-Related Eye Disease Study severity scale and simplified severity scale for age-related macular degeneration. Arch Ophthalmol 123(11):1598–1599 Wang JJ, Foran S, Smith W, Mitchell P (2003) Risk of agerelated macular degeneration in eyes with macular drusen or hyperpigmentation: the Blue Mountains Eye Study cohort. Arch Ophthalmol 121(5):658–663 Macular Photocoagulation Study Group (1993) Five-year follow-up of fellow eyes of patients with age-related macular degeneration and unilateral extrafoveal choroidal neovascularization.

Ho et al. 5 1 2 5 Fig. , Scottish ORs and 95% CIs were calculated using the random effects model of the DerSimoninian and Laird method. Scholl et al. only investigated associations with geographic atrophy, whereas Cui et al. and Pei et al. only investigated neovascular AMD 56, 138]; several studies have shown a strong correlation between AMD and multiple genetic variants in the 10q26 locus [62, 99, 139–152]. Nevertheless, controversy remains regarding the source of the genetic effect at this region due to the high linkage disequilibrium (LD) between three genes: the Pleckstrin Homology Domain-containing Protein family A member 1 (PLEKHA1), LOC387715 or age-related maculopathy susceptibility 2 (ARMS2) gene, and high temperature requirement factor A1 (HTRA1) gene.

Eapen D, Kalra GL, Merchant N, Arora A, Khan BV (2009) Metabolic syndrome and cardiovascular disease in South Asians. Vasc Health Risk Manag 5:731–743 12. Misra A, Khurana L (2009) The metabolic syndrome in South Asians: epidemiology, determinants, and prevention. Metab Syndr Relat Disord 7(6):497–514 13. Jampol LM, Tielsch J (1992) Race, macular degeneration, and the Macular Photocoagulation Study. Arch Ophthalmol 110(12):1699–1700 14. Pieramici DJ, Bressler NM, Bressler SB, Schachat AP (1994) Choroidal neovascularization in black patients.

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