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By G. J. Thomas Jr., A. H.-J. Wang (auth.), Professor Dr. Fritz Eckstein, Dr. David M. J. Lilley (eds.)

Molecular biology has consistently been a self-discipline of quick improvement. regardless of this, we're shortly experiencing a interval of extraordinary proliferation of knowledge in nucleic acid reviews and molecular biology. those parts are in detail interwoven, in order that every one impacts the opposite to their mutual gain. The fast development in info results in ever-increasing specialization, in order that it turns into more and more tough for a scientist to maintain abreast of advancements in all of the quite a few points of the sector, even though an up to date wisdom of the sector as an entire is extremely fascinating. With this history in brain we current the sequence Nucleic Acids and Molecular Biology. It contains centred evaluation articles via lively researchers who file at the latest advancements of their parts of specific interest.

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2. Class I viruses, fd and IKe (also Ifl, data not shown in Fig. 13), contain similar DNA structures. These have C3' endo/anti nucleoside conform a- Laser Raman Spectroscopy of Nucleic Acids 27 tions, but lack the regular phosphodiester backbone geometry found in either A-DNA or B-DNA. 3. The Class II viruses (Pfl, Xf, Pf3) do not all contain similar DNA conforma tions. Pfl and Xf share C2' endo /anti nucleoside conformers, but C3' endo/anti conformers are indicated for PO. , encompassing a wide range of (ex, values.

Pract Spectrosc Ser 1C :717 -872 Thomas GJ, Jr, Medeiros GC, Hartman KA (1971) The dependence of Raman scattering on the conformation of ribosomal RNA. Biochem Biophys Res Commun 44: 587-592 Thomas GJ, Jr, Benevides JM, Prescott B (1986) DNA and RNA structures in crystals, fibers and solutions by Raman spectroscopy with applications to nucleoproteins. , Xf and Pf3. Biochemistry 27 (in press) Wang AH-J (1987) Interactions between antitumor drugs and DNA. In: Eckstein F, Lilley DMJ (eds) Nucleic acids and molecular biology, vol 1.

Thus, poly (rA) 'poly(dT) is apparently a true he- A c 500 1000 em-' 1500 Fig. 10. 1 M NaCl (B-form structure); C poly (dA-

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